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ضد التهابی
As wounds heal, the local macrophage population transitions from predominantly pro-inflammatory (M1-like phenotypes) to anti-inflammatory (M2-like phenotypes).
In acute wounds, as the tissue begins to repair, the overall macrophage population transitions to one that promotes anti-inflammatory effects (traditionally and collectively referred to as "M2" macrophages), and the migration and proliferation of fibroblasts, keratinocytes and endothelial cells to restore the dermis, epidermis and vasculature, respectively.
For example, the type of lipids produced by sebocytes can impact whether local macrophages take on pro- or anti-inflammatory characteristics, which could potentially impede or promote healing in that area (Lovaszi et al.
Multiple monocyte types, categorized as pro-inflammatory and anti-inflammatory, are attracted to the wound site (Ogle et al.
The second type of recruited monocytes consists of anti-inflammatory monocytes, which have a longer half-life (>2 days, in mice).
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